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Search Results for " sirt5 inhibitor 1 "

8

Compounds

Cat No. Product Name Synonyms Targets
T12921 SIRT5 inhibitor 1 Sirtuin
SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases.
T61457 SIRT5 inhibitor 4
SIRT5 inhibitor 4 (compound 11) is a highly effective and selective inhibitor of SIRT5, with IC50 values of 26.4 μM and >400 μM for SIRT5 and other SIRT subtypes, respectively [1].
T72637 SIRT5 inhibitor 5 Sirtuin
SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 µM, and does not interact with the NAD+-binding pocket [1].
T78857 SIRT5 inhibitor 9 Sirtuin
SIRT5 inhibitor 9 (compound 14), with an IC50 of 4.07 μM, is a competitive inhibitor of the sirtuin SIRT5, exhibiting potential anticancer properties [1].
T78856 SIRT5 inhibitor 8 Sirtuin
SIRT5 inhibitor 8 (compound 10) serves as a competitive inhibitor of sirtuin SIRT5, exhibiting an IC50 of 5.38 μM, and possesses anticancer potential [1].
T78802 SIRT5 inhibitor 6 Sirtuin
SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential for treating septic acute kidney injury (AKI) in vivo [1].
T78803 SIRT5 inhibitor 7 Sirtuin
SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating protein succinylation and attenuating pro-inflammatory cytokine release. It demo...
T75303 Suramin
Suramin is a reversible, competitive inhibitor of protein-tyrosine phosphatases (PTPases) [1], demonstrating potent inhibition against sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) [2]. It a...
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